Trichloro(1H,1H,2H,2H-heptadecafluorodecyl)silane

• CAS: 78560-44-8
• Catalog Number: ACM78560448
• Category: Main Products
• Molecular Weight: 581.56
• Molecular Formula: C₁₀H₄Cl₃F₁₇Si
• Synonyms: trichloro(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)silane
• IUPAC Name: trichloro(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)silane
• SMILES: C(C[Si](Cl)(Cl)Cl)C(C(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F
• InChI Key: VIFIHLXNOOCGLJ-UHFFFAOYSA-N
• Boiling Point: 216ºC
• Flash Point: >110ºC
• Density: 1.7
• Appearance: colourless to straw-coloured liquid with an odour of hydrogen chloride
• EC Number: 616-629-4
• Exact Mass: 579.88800
• Hazard Statements: C: Corrosive
• Packing Group: II
• Safety Description: S26-S36/37/39-S45
• Stability: Stable. Flammable. Incompatible with strong oxidizing agents.

Case Study

Trichloro(1H,1H,2H,2H-heptadecafluorodecyl)silane as a Surface-Enrichment Agent for Photodynamic Antibacterial Membranes

Sun, Jing, et al. Journal of Colloid and Interface Science 559 (2020): 197-205.

Trichloro(1H,1H,2H,2H-heptadecafluorodecyl)silane (THFS) serves as a low-surface-energy fluorinated modifier for mesoporous silica nanoparticles (MSNs), enabling self-enrichment of methylene blue (MB)-loaded MSNs onto electrospun nanofiber surfaces to enhance reactive oxygen species (ROS) generation and photodynamic antibacterial activity.
Fabrication Process: MSNs (~280 nm) were loaded with MB (12 μg/mg) and then modified with THFS (38 μL per 0.1 g MSN@MB) in anhydrous toluene at 0 °C for 3 h. The resulting MSNF@MB was mixed with zein/polycaprolactone (1:1 w/w) and electrospun (22 kV, 0.9 mL/h) into nanocomposite membranes (Z/PCL@MSNF@MB).
Performance Evaluation: THFS functionalization enabled spontaneous surface migration of MSNF@MB during electrospinning, as confirmed by SEM and XPS (F 1s peak at 288 eV). The membrane achieved a water contact angle of 140.5° (vs. 107.6° without THFS) and significantly enhanced singlet oxygen production (DPBF assay). Upon 660 nm visible light irradiation (20 min), the Z/PCL@MSNF@MB membrane killed >97% of both S. aureus and E. coli, far outperforming non-fluorinated controls (~80% survival). Cytotoxicity tests showed >90% viability for L929 fibroblasts, confirming biocompatibility.
Conclusion: THFS is an effective surface-enrichment agent that boosts photodynamic antibacterial efficiency by concentrating ROS generators on fiber surfaces, ideal for infection-resistant wound dressings.

Trichloro(1H,1H,2H,2H-heptadecafluorodecyl)silane as a Low-Surface-Energy Modifier for Superhydrophobic Cellulose Nanofiber Assemblies

Bashar, M. Mahbubul, et al. RSC advances 7.59 (2017): 37168-37174.

Trichloro(1H,1H,2H,2H-heptadecafluorodecyl)silane (THFS) serves as an effective fluorinated silane coupling agent that imparts superhydrophobicity and oleophilicity to cellulose nanofibers (CNFs) via simple one-pot surface modification, enabling highly efficient gravity-driven oil-water separation.
Fabrication Process: Paste-form CNF was solvent-exchanged from water to AK-225, then reacted with THFS (1.7-6.8 mM in AK-225) at ambient temperature for 8 h. The modified CNF was dispersed in AK-225 (0.1 wt%), drop-cast onto substrates or steel mesh (150 µm pore size), and vacuum-dried.
Performance Evaluation: THFS modification was confirmed by FT-IR (C-F peaks at 1235/1205 cm^-1) and XPS (CF3 at 293.8 eV, CF2 at 291.3 eV). The modified CNF assembly achieved a water contact angle (WCA) of 160±2° (pristine CNF: 13°) and an octane contact angle <35°, with a calculated air-fraction area of 90.8%. The coating exhibited thermal stability up to 220 °C and maintained WCA >150° after immersion in hot water (90 °C), artificial seawater, and pH 1/14 solutions. On THFS-coated steel mesh, gravity-driven separation efficiency exceeded 99% for various hydrocarbons (hexane, octane, kerosene) and remained stable over 50 cycles.
Conclusion: THFS is a versatile, low-surface-energy modifier that converts hydrophilic CNF into durable superhydrophobic coatings, ideal for scalable oil-water separation in harsh environments.

Trichloro(1H,1H,2H,2H-heptadecafluorodecyl)silane as a Hydrophobic Modifier for Mesoscale Self-Assembly of Microplatelets

Murphy, Connor, et al. Plos one 16.2 (2021): e0246453.

Trichloro(1H,1H,2H,2H-heptadecafluorodecyl)silane (THFS) serves as an effective surface-functionalization agent that renders microfabricated polysilicon microplatelets (100 μm wide, 30 μm thick) highly hydrophobic, enabling rapid ultrasonic-assisted self-assembly into two- and three-dimensional ordered structures.
Fabrication Process: Microplatelets were stirred with THFS (200 μL in 10 mL ethanol) for 24 h at room temperature, washed, then mixed with lauryl methacrylate. The suspension was placed in a glass tube with deionized water and subjected to 40 kHz ultrasonic waves for 30 min.
Performance Evaluation: THFS functionalization imparted strong hydrophobicity to all faces of the microplatelets. Under sonication, building blocks self-assembled into large-area two-dimensional tessellated patterns (>10 mm²) on the concave bottom of the glass tube. Simultaneously, at the water-air interface, three-dimensional multi-layered crystalline stacks formed, extending both in-plane and perpendicularly. The structures mimicked natural nacre with well-aligned, defect-minimized organization. The process took only 30 min, significantly faster than conventional methods (1-3 days). The self-assembled aggregates were stable and several millimeters in size.
Conclusion: THFS is a key low-surface-energy modifier that drives rapid, large-scale mesoscale self-assembly, promising for bio-inspired structural materials and surface coatings.