CAS
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JWJ-01-306
Catalog Number
ACM-MG-00025
Category
Molecular Glues
Molecular Weight
574.98
Molecular Formula
C28H26ClF3N4O4
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Specification
Description
JWJ-01-306 is a molecular glue that targets the C2H2 zinc finger transcription factor ZBTB11. JWJ-01-306 degrades ZBTB11, reduces the oxidative phosphorylation (OXPHOS) and tricarboxylic acid (TCA) cycle, and inhibits the proliferation of KAS-resistant PDAC cells. JWJ-01-306 exhibits good pharmacokinetic characteristics in mouse model.
SMILES
FC(F)(F)C1=C(Cl)C=CC(CCNC2(CCC2)C3=CC(NC(C(N4C5CCC(NC5=O)=O)=O)=CC4=O)=CC=C3)=C1
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