CAS
--- Purity
≥95% (HPLC)
--- Purity
≥95% (HPLC)
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KMG-1068
Catalog Number
ACM-MG-00027
Category
Molecular Glues
Molecular Weight
426.49
Molecular Formula
C21H22N4O4S
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- Product Description
- Case Study
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Specification
Description
KMG-1068 (Compound 4a), a molecular glue, is a GSPT1/2 degrader. KMG-1068 effectively induces the CRBN-dependent degradation of GSPT1/2 by binding to the IMiD binding site on CRBN, facilitating the formation of a ternary complex with GSPT1/2. KMG-1068 is promising for research of cancers.
SMILES
O=C1C(C)=C(C)N=CN1CC(NC2=NC(C(OC)=O)=C(CCC3=CC=CC=C3)S2)=O
Shipping
Generally, shipped at room temperature in continental US; may vary elsewhere.
Storage Conditions
Please store the product under the recommended conditions.
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