Fmoc-Asp(biotinyl-PEG)-OH

• Catalog Number: ACMA00051078
• Category: Amino Acids
• Molecular Weight: 783.93
• Description: In contrast to Fmoc-Lys(biotin)-OH, this novel biotin-labeled amino acid has excellent solubility in DMF and other solvents used in Fmoc SPPS. The PEG-spacer restricts hindrance between the peptide and avidin, leading to better biotin binding. Furthermore, the hydrophilic nature of the PEG minimizes non-specific interactions that can arise from the spacer group becoming buried in the hydrophobic pocket of proteins.; Associated Protocols and Technical Articles; Biotinylation Reagents for Peptide Synthesis; Literature references; B. Baumeister, et al. (2003) Biopolymers, 71, 339.
• Synonyms: Fmoc-Asp(biotinyl-PEG)-OH, N-α-Fmoc-N-γ-(N-biotinyl-3-(2-(2-(3-aminopropyloxy)-ethoxy)-ethoxy)-propyl)-L-asparagine
• Application: Peptide synthesis.
• Assay: ≥95.0% (HPLC); ≥98% (TLC)
• Form: powder
• Functional Group: biotin
• Quality Level: 200
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: 2-8℃