Sun S1, Liang N2, Gong X3, An W4, Kawashima Y5, Cui F6, Yan P7.
Int J Mol Sci. 2016 Dec 28;18(1). pii: E54. doi: 10.3390/ijms18010054.In this study, we designed and developed a new drug delivery system of multifunctional composite microcapsules for oral administration of insulin. Firstly, in order to enhance the encapsulation efficiency, insulin was complexed with functional sodium deoxycholate to form insulin-sodium deoxycholate complex using hydrophobic ion pairing method. Then the complex was encapsulated into poly(lactide-co-glycolide) (PLGA) nanoparticles by emulsion solvent diffusion method. Read More