Blay G1, Cano J, Cardona L, Fernández I, Muñoz MC, Pedro JR, Vila C.
J Org Chem. 2012 Dec 7;77(23):10545-56. doi: 10.1021/jo3013594. Epub 2012 Nov 12.Experimental and theoretical studies on the structure of several complexes based on (R)-3,3'-Br(2)-BINOL ligand and group (IV) metals used as catalysts in an enantioselective Friedel-Crafts alkylation of indoles with α,β-unsaturated ketones have been carried out. NMR spectroscopic studies of these catalysts have been performed, which suggested that at room temperature the catalysts would form a mon ... Read More