Triisopropylsilyl trifluoromethanesulfonate

• CAS: 80522-42-5
• Catalog Number: ACM80522425-1
• Category: Silylation Reagents
• Molecular Weight: 306.42
• Molecular Formula: C10H21F3O3SSi
• Synonyms: TIPS triflate, Trifluoromethanesulfonic acid triisopropylsilyl ester, Triisopropylsilyl triflate
• Boiling Point: 45-46 °C/0.03 mmHg
• Flash Point: 100 °C
• Density: 1.14 g/mL at 25 °C (lit.)
• Storage: Moisture Sensitive. Ambient temperatures.
• Physical State: Liquid
• Refractive Index: 1.413-1.415

Synthetic Use

Upstream Synthesis Route 1

• 6485-79-6
• 1493-13-6

• 80522-42-5

Reference: [1] Tetrahedron Letters, 1981, vol. 22, # 36, p. 3455 - 3458
[2] Advanced Synthesis and Catalysis, 2009, vol. 351, # 7-8, p. 1035 - 1040
[3] European Journal of Organic Chemistry, 2017, vol. 2017, # 17, p. 2512 - 2539
[4] European Journal of Organic Chemistry, 2017, vol. 2017, # 20, p. 2883 - 2915

Upstream Synthesis Route 2

• 1493-13-6
• 24400-84-8

• 80522-42-5

Reference: [1] Synthesis, 1997, # 7, p. 744 - 746

Upstream Synthesis Route 3

• 13154-24-0
• 1493-13-6

• 80522-42-5

Reference: [1] Bulletin of the Chemical Society of Japan, 1990, vol. 63, # 4, p. 1039 - 1048
[2] Tetrahedron Letters, 1987, vol. 28, # 49, p. 6191 - 6194

Downstream Synthesis Route 1

• 6881-49-8
• 80522-42-5

• 137812-10-3

Reference: [1]Canadian Journal of Chemistry,1991,vol. 69,p. 1487 - 1497

Downstream Synthesis Route 2

• 6710-62-9
• 16075-82-4
• 80522-42-5

• 133721-57-0

Reference: [1]Obrecht, Daniel
[Helvetica Chimica Acta, 1991, vol. 74, # 1, p. 27 - 46]
[2]Obrecht, Daniel
[Helvetica Chimica Acta, 1991, vol. 74, # 1, p. 27 - 46]

Downstream Synthesis Route 3

• 69778-83-2
• 80522-42-5

• 109826-87-1

Reference: [1]Tetrahedron Letters,1986,vol. 27,p. 5285 - 5288

* For details of the synthesis route, please refer to the original source to ensure accuracy.