trans-4-Hydroxy-L-proline suitable for cell culture

• CAS: 51-35-4
• Catalog Number: ACM51354-3
• Category: Amino Acids
• Molecular Weight: 131.13
• Description: Trans-4-hydroxy-L-proline is an isomer of hydroxyproline used as a chiral building block in the production of many pharmaceuticals like neuroexcitatory kainoids.
• Synonyms: 4-Hydroxyproline, Hydroxyproline, (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid, Hyp
• SMILES: O[C@H]1CN[C@@H](C1)C(O)=O
• InChI: 1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
• InChI Key: PMMYEEVYMWASQN-DMTCNVIQSA-N
• Melting Point: 273 ℃(dec.) (lit.)
• Solubility: H2O: 50 mg/mL
• Application: Peptide synthesis.
• Assay: ≥98.5%
• Beilstein: 81441
• Color: colorless
• EC Number: 200-091-9
• Form: crystalline
• Impurity Content: endotoxin, tested
• MDL Number: MFCD00064320
• NACRES: NA.26
• PubChem ID: 24895700
• Quality Level: 200
• Storage Temperature: 2-8℃
• Technique: cell culture | mammalian: suitable

Synthetic Use

Upstream Synthesis Route 1

• 618-28-0

• 3398-22-9
• 51-35-4

Reference: [1] Chemistry of Materials, 2011, vol. 23, # 5, p. 1280 - 1287

Downstream Synthesis Route 1

• 51-35-4

• 13500-53-3

Reference: [1] Journal of Organic Chemistry, 2006, vol. 71, # 13, p. 5004 - 5007

Downstream Synthesis Route 2

• 51-35-4

• 2584-71-6

Reference: [1] Tetrahedron Asymmetry, 2003, vol. 14, # 20, p. 3141 - 3152

Downstream Synthesis Route 3

• 501-53-1
• 51-35-4

• 13504-85-3

Reference: [1]Bioorganic and Medicinal Chemistry Letters,2000,vol. 10,p. 1845 - 1847

Downstream Synthesis Route 4

• 51-35-4
• 4457-32-3

• 96034-57-0

Reference: [1]Bioorganic and Medicinal Chemistry Letters,2000,vol. 10,p. 95 - 99

Downstream Synthesis Route 5

• 27151-65-1
• 108-24-7
• 51-35-4

• 79562-55-3

Reference: [1]Journal of Organic Chemistry,1984,vol. 49,p. 5164 - 5174

* For details of the synthesis route, please refer to the original source to ensure accuracy.