Saquinavir

• CAS: 127779-20-8
• Catalog Number: ACM127779208
• Category: Inhibitors
• Molecular Weight: 670.84
• Molecular Formula: C₃₈H₅₀N₆O₅
• Description: Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.36 μM.
• Synonyms: n1-[(1s,2r)-3-[(3s,4as,8as)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1h)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-butanediamide;SAGUINAVIR;SAQUINAVIR;2-[[2-METHYL-3-(TRIFLUOROMETHYL)PHENYL]AMINO]PYRIDINE-3-CARBOXYLIC ACID;(2S)-N-[(2S,3R)-4-[(3S,4AS,8AS)-3-(TERT-BUTYLCARBAMOYL)-3,4,4A,5,6,7,8,8A-OCTAHYDRO-1H-ISOQUINOLIN-2-YL]-3-HYDROXY-1-PHENYL-BUTAN-2-YL]-2-(QUINOLINE-2-CARBONYLAMINO)BUTANEDIAMIDE;FLUNIXIN;FLUNIXINE;SAQUINAVIRMESYLATE(SUBJECTTOPATENTFREE)
• Canonical SMILES: O=C(N[C@@H](CC(N)=O)C(N[C@@H](CC1=CC=CC=C1)[C@H](O)CN2[C@H](C(NC(C)(C)C)=O)C[C@@](CCCC3)([H])[C@@]3([H])C2)=O)C4=NC5=CC=CC=C5C=C4
• Appearance: Solid
• Storage: Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
• Shipping: Can be shipped at room temperature, where not in use may vary.

Custom Q&A

What is the molecular formula of saquinavir?

The molecular formula of saquinavir is C38H50N6O5.

What is the molecular weight of saquinavir?

The molecular weight of saquinavir is 670.8 g/mol.

When was saquinavir created?

Saquinavir was created on June 24, 2005.

What is the primary amino group involved in the synthesis of saquinavir?

The primary amino group involved is (2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-ylamine.

What is the role of saquinavir?

Saquinavir has the role of being an HIV protease inhibitor and an antiviral drug.

What is the mechanism of action of saquinavir?

The mechanism of action of saquinavir is as an HIV Protease Inhibitor and Cytochrome P450 3A Inhibitor.

What is one synonym for saquinavir?

One synonym for saquinavir is Invirase.

What is the PubChem CID for saquinavir?

The PubChem CID for saquinavir is 441243.

What is the FDA Pharm Class of saquinavir?

The FDA Pharm Class of saquinavir is as an HIV Protease Inhibitor.

How is the oral bioavailability of saquinavir improved?

The oral bioavailability of saquinavir is improved by co-administration with ritonavir, which increases the bioavailability and serum concentrations of saquinavir.