Perfluorohexanesulfonamide

• CAS: 41997-13-1
• Catalog Number: ACM41997131
• Category: Main Products
• Molecular Weight: 399.13
• Molecular Formula: C6H2F13NO2S
• Synonyms: 1,1,2,2,3,3,4,4,5,5,6,6,6-Tridecafluorohexane-1-sulfonamide
• Melting Point: 122 °C
• Appearance: Solid

Case Study

Assessing the Impact of Perfluorohexanesulfonamide on Microbial Bioremediation Processes

Cook, Emily K., et al. Environmental Science & Technology 58.20 (2024): 8792-8802.

The remediation of sites co-contaminated with chlorinated solvents (e.g., TCE) and aromatic hydrocarbons (e.g., BTEX) is often complicated by the presence of Per- and Polyfluoroalkyl Substances (PFAS) from aqueous film-forming foams (AFFFs). Effective bioremediation relies on specific microbial communities, whose activity may be inhibited by PFAS. This study investigated the inhibitory potential of the PFASs including perfluorohexanesulfonamide (FHxSA) on key microorganisms involved in anaerobic and aerobic biodegradation processes.
Testing Method: The impact of FHxSA was evaluated in parallel with other surfactants, including its zwitterionic precursor (AmPr-FHxSA), the anionic perfluorohexanesulfonic acid (PFHxS), and a non-fluorinated control (SDS). Individual PFAS were applied at concentrations of 1-10 μM. Three distinct microbial cultures were exposed.
Key Findings:
· Both FHxSA and its precursor AmPr-FHxSA inhibited the aerobic BTEX-degrading culture. This inhibitory effect was more pronounced than that caused by the anionic PFHxS at equivalent concentrations. The anaerobic TCE-dechlorinating coculture was not inhibited by individual PFAS exposures, including FHxSA. Similarly, the anaerobic toluene-degrading culture showed no inhibition from individual PFASs or diluted AFFF.
· Metabolite analysis indicated that exposure to surfactants, including FHxSA, altered amino acid concentrations in the cultures. The aerobic BTEX culture showed lower concentrations of all amino acids upon exposure, while the anaerobic TCE culture exhibited an increase, suggesting different stress response mechanisms potentially related to cell membrane synthesis and protein stress signaling.

Custom Q&A

What is the molecular formula of Perfluorohexanesulfonamide?

The molecular formula of Perfluorohexanesulfonamide is C6F13SO2NH2C6H2F13NO2S.

What are the synonyms for Perfluorohexanesulfonamide?

The synonyms for Perfluorohexanesulfonamide include FHxSA, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluorohexane-1-sulfonamide, and SODIUM PERFLUOROHEXANESULFONAMIDE.

What is the molecular weight of Perfluorohexanesulfonamide?

The molecular weight of Perfluorohexanesulfonamide is 399.13 g/mol.

When was Perfluorohexanesulfonamide created?

Perfluorohexanesulfonamide was created on October 26, 2006.

What is the IUPAC name of Perfluorohexanesulfonamide?

The IUPAC name of Perfluorohexanesulfonamide is 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluorohexane-1-sulfonamide.

What is the InChI of Perfluorohexanesulfonamide?

The InChI of Perfluorohexanesulfonamide is InChI=1S/C6H2F13NO2S/c7-1(8,3(11,12)5(15,16)17)2(9,10)4(13,14)6(18,19)23(20,21)22/h(H2,20,21,22).

What is the InChIKey of Perfluorohexanesulfonamide?

The InChIKey of Perfluorohexanesulfonamide is WDZLGCSJJWEQJO-UHFFFAOYSA-N.

What is the Canonical SMILES of Perfluorohexanesulfonamide?

The Canonical SMILES of Perfluorohexanesulfonamide is C(C(C(C(F)(F)S(=O)(=O)N)(F)F)(F)F)(C(C(F)(F)F)(F)F)(F)F.

What is the CAS number of Perfluorohexanesulfonamide?

The CAS number of Perfluorohexanesulfonamide is 41997-13-1.

What is the XLogP3-AA value of Perfluorohexanesulfonamide?

The XLogP3-AA value of Perfluorohexanesulfonamide is 3.5.