Negletein

• CAS: 29550-13-8
• Catalog Number: ACM29550138
• Category: Inhibitors
• Molecular Weight: 284.26
• Molecular Formula: C16H12O5
• Description: Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 and 10.8 μM, respectively.

Synthetic Use

Upstream Synthesis Route 1

• 742073-28-5

• 29550-13-8

Reference: [1]Iyer; Venkataraman
[Proceedings - Indian Academy of Sciences, Section A, 1953, # 37, p. 629,641]

Upstream Synthesis Route 2

• 119892-40-9

• 29550-13-8

Reference: [1]Sastri; Seshadri
[Proceedings - Indian Academy of Sciences, Section A, 1946, # 23, p. 273,276]

Downstream Synthesis Route 1

• 29550-13-8
• 108-24-7

• 94465-55-1

Reference: [1]Iyer; Venkataraman
[Proceedings - Indian Academy of Sciences, Section A, 1953, # 37, p. 629,641]
Sastri; Seshadri
[Proceedings - Indian Academy of Sciences, Section A, 1946, # 23, p. 273,276]

* For details of the synthesis route, please refer to the original source to ensure accuracy.