N-Methyl-N-(trimethylsilyl)trifluoroacetamide

• CAS: 24589-78-4
• Catalog Number: ACM24589784
• Category: Silylation Reagents
• Molecular Weight: 199.25
• Molecular Formula: C6H12F3NOSi
• Synonyms: N-Trimethylsilyl-N-methyl trifluoroacetamide, MSTFA
• Boiling Point: 130-132 °C (lit.)
• Melting Point: 98-100 °C
• Flash Point: 25 °C - closed cup
• Density: 1.075 g/mL at 25 °C (lit.)
• Application: N-Methyl-N-(trimethylsilyl)trifluoroacetamide serves as a versatile silylating reagent primarily utilized in forming volatile derivatives suitable for GC-MS analysis Its application extends to functioning as a pharmaceutical intermediate and as a metabolite of Famprofazone in humans Additionally it plays a crucial role in the detection of steroid hormones such as 17-alpha-ethynylestradiol and estrone MSTFA offers an alternative to diazomethane as a derivatizing reagent enhancing its utility in various analytical processes
• Storage: Moisture Sensitive. Ambient temperatures.
• Physical State: Liquid

Synthetic Use

Downstream Synthesis Route 1

• 1852-17-1
• 24589-78-4

• 815-06-5
• 18132-77-9

Reference: [1] Tetrahedron, 1997, vol. 53, # 12, p. 4371 - 4386

Downstream Synthesis Route 2

• 24589-78-4

• 10457-14-4

Reference: [1] Phytochemistry, 1999, vol. 50, # 2, p. 337 - 338

Downstream Synthesis Route 3

• 24589-78-4
• 110-58-7

• 815-06-5
• 18107-22-7

Reference: [1] Phosphorus, Sulfur and Silicon and the Related Elements, 1992, vol. 68, # 1-4, p. 25 - 36

Downstream Synthesis Route 4

• 3471-31-6
• 24589-78-4

• 55887-55-3

Reference: [1]Arzneimittel-Forschung/Drug Research,1983,vol. 33,p. 885 - 888

* For details of the synthesis route, please refer to the original source to ensure accuracy.