N-Carboethoxy phthalimide

• CAS: 22509-74-6
• Catalog Number: ACM22509746
• Category: Main Products
• Molecular Weight: 219.19
• Molecular Formula: C₁₁H₉NO₄
• Synonyms: N-carbethoxy-phthalimide; Nefkins reagent; 2-Isoindolinecarboxylic acid,1,3-dioxo-,ethyl ester; Ethyl phthalimide-N-carboxylate; 2H-Isoindole-2-carboxylic acid,1,3-dihydro-1,3-dioxo-,ethyl ester; Ethyl N-phthaloylcarbamate; Phthalimide-N-carbethoxy; N-Carboethoxyphthalimide; N-Ethoxycarbonylphthalimide; 1,3-Dihydro-1,3-dioxo-2H-isoindole-2-carboxylic acid,ethyl ester; N-Carbethoxyphthalimide; Ethyl 1,3-dioxo-2-isoindolinecarboxylate
• IUPAC Name: ethyl 1,3-dioxoisoindole-2-carboxylate
• Boiling Point: 353.9ºC at 760 mmHg
• Melting Point: 90-92ºC
• Flash Point: 167.8ºC
• Density: 1.398 g/cm³
• Appearance: White crystalline powder
• Exact Mass: 219.05300
• Hazard Statements: Xn:Harmful
• Safety Description: S26-S36/37/39
• Stability: Stable under normal temperatures and pressures.
• WGK Germany: 3

Synthetic Use

Downstream Synthesis Route 1

• 56-41-7
• 22509-74-6

• 4192-28-3

Reference: [1] Angewandte Chemie - International Edition, 2013, vol. 52, # 51, p. 13588 - 13592

Downstream Synthesis Route 2

• 1676-73-9
• 22509-74-6

• 88784-33-2

Reference: [1] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 11, p. 1587 - 1592
[2] Tetrahedron Letters, 1994, vol. 35, # 3, p. 393 - 396

Downstream Synthesis Route 3

• 22509-74-6
• 2450-71-7

• 7223-50-9

Reference: [1] European Journal of Organic Chemistry, 2004, # 16, p. 3447 - 3458

Downstream Synthesis Route 4

• 22509-74-6

• 127-07-1

Reference: [1]Justus Liebigs Annalen der Chemie,1968,vol. 712,p. 208 - 213

Downstream Synthesis Route 5

• 327-56-0
• 22509-74-6

• 1221409-47-7

Reference: [1]Location in patent: experimental part
Kalisiak, Jarostaw; Trauger, Sunia A.; Kalisiak, Ewa; Morita, Hirotoshi; Fokin, Valery V.; et al.
[Journal of the American Chemical Society, 2009, vol. 131, p. 378 - 386]
[2]Hu, Wenqiag; Hesse, Manfred
[Helvetica Chimica Acta, 1996, vol. 79, # 2, p. 548 - 559]
[3]Sosnovsky; Lukszo
[Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1986, vol. 41, # 1, p. 122 - 129]
[4]Sosnovsky, George; Lukszo, Jan
[Zeitschrift fur Naturforschung, B: Chemical Sciences, 1994, vol. 49, # 11, p. 1580 - 1585]
[5]Chitkul, Bordin; Bradley, Mark
[Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 20, p. 2367 - 2369]

Downstream Synthesis Route 6

• 6346-09-4
• 22509-74-6

• 32464-55-4

Reference: [1]Zhang, Qi; Chen, Kai; Rao, Weihao; Zhang, Yuejun; Chen, Fa-Jie; Shi, Bing-Feng
[Angewandte Chemie - International Edition, 2013, vol. 52, # 51, p. 13588 - 13592][Angew. Chem., 2013, vol. 125, # 51, p. 13833 - 13837,5]

* For details of the synthesis route, please refer to the original source to ensure accuracy.