Magnolia grandiflora oil

• CAS: 68917-19-1
• Catalog Number: ACM68917191
• Category: Main Products
• Molecular Weight: 36.46094;g/mol
• Molecular Formula: ClH
• IUPAC Name: chlorane
• SMILES: Cl
• InChI Key: VEXZGXHMUGYJMC-UHFFFAOYSA-N
• EC Number: 231-595-7
• UN Number: 1050

Case Study

Analysis of Magnolia grandiflora Flower Oil for Potential Bioactive Applications

Morshedloo, Mohammad Reza, et al. Natural product research 31.24 (2017): 2857-2864.

Magnolia grandiflora is traditionally used in cosmetic formulations, particularly for skin conditions. This study analyzed the chemical composition and biological activities of the essential oil extracted from Magnolia grandiflora flowers, focusing on its antioxidant potential and in-vitro cytotoxic effects on selected human tumour cell lines.
· Chemical profile: GC-MS identified fifteen components in the flower oil. Sesquiterpene hydrocarbons comprised the bulk of the volatile fraction (~64%), with β-elemene at 14.33%, bicyclogermacrene at 10.33%, germacrene D at 7.59% and detectable levels of (E)-caryophyllene. Total phenolic content, expressed as gallic acid equivalents, was measured at 2.01 ± 0.4 mg/g.
· Antioxidant activity: There was a variable response across the antioxidant assays performed: a very weak DPPH scavenging capacity (est. 1,270-fold lower than the Trolox positive control), moderate ABTS assay activity (TEAC = 95.02 ± 0.4 µmol TE/g), and moderate reducing capacity in the FRAP assay (TEAC = 24.4 ± 2.3 µmol TE/g). Researchers attributed the low DPPH reactivity to a predominance of terpene hydrocarbons that are generally poor hydrogen donors.
· When tested against A375 (melanoma), MDA-MB-231 (breast) and T98G (glioblastoma) cells, the essential oil reduced cell proliferation with IC50 values near 35 µg/mL for all three lines, indicating a lack of selective cytotoxicity in these assays. Isolated β-elemene displayed greater potency, with reported IC50 values of 15 µg/mL (A375), 23.26 µg/mL (MDA-MB-231) and 20.26 µg/mL (T98G).

Evaluation of Magnolia grandiflora Seed Oil as a Biting Deterrent against Aedes aegypti Mosquitoes

Ali, Abbas, et al. Molecules 25.6 (2020): 1359.

This study evaluated essential oils distilled from five Magnolia grandiflora plant parts (leaf, flower, immature fruit, mature fruit, seed) for activity against Aedes aegypti. The seed essential oil stood out for biting-deterrent potency comparable to DEET (biting deterrence index, BDI = 0.89) and for containing medium-chain aliphatic alcohols (notably 1-decanol at 3.3%) implicated as active components.
· Chemical profiles varied markedly by plant part. Immature and seed oils were richer in sesquiterpene hydrocarbons (seed ≈31.5%; immature fruit ≈32%). The seed oil was unique for containing higher proportions of fatty acids and esters (fatty acids/esters ≈5.1%; saturated aliphatic esters 10.9%), hexadecanoic acid (2.9%), methyl chavicol (2.6%) and eugenol (1.3%). Notably, the seed oil contained aliphatic alcohols 1-octanol (6.2%), 1-decanol (3.3%) and 1-heptanol, compounds that were absent or at low levels in other oils.
· In laboratory bioassays 1-decanol showed repellency and contact toxicity metrics that compared favorably with DEET and other oil fractions: 1-decanol PNB = 0.8 (DEET PNB = 0.8), MED (A & K assay) = 6.25 (DEET MED = 12.5) and LC50 = 4.8 ppm (most toxic compound tested). Fruit oils (immature and mature) showed high larvicidal/adulticidal toxicity at 125 ppm, whereas leaf, flower and seed oils produced lower mortality at that dose (20%, 0% and 50%, respectively). These results identify seed oil and its 1-decanol fraction as lead natural products for follow-up in mosquito-repellent and insecticidal product development.