Kt5823

• CAS: 126643-37-6
• Catalog Number: ACM126643376
• Category: Inhibitors
• Molecular Weight: 495.5259
• Molecular Formula: C₂₉H₂₅N₃O₅
• Description: KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an Ki value of 0.23 μM, it also inhibits PKA and PKC with Ki values of 10 μM and 4 μM, respectively. KT5823 is a staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na+/I- symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation.