ISCK03

• CAS: 945526-43-2
• Catalog Number: ACM945526432-2
• Category: Inhibitors
• Molecular Weight: 355.46
• Molecular Formula: C19H21N3O2S
• Description: ISCK03 is a potent c-kit inhibitor. ISCK03 inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. ISCK03 also inhibited p44/42 ERK mitogen-activated protein kinase (MAPK) phosphorylation, which is known to be involved in SCF/c-kit downstream signaling. ISCK03 might be used as skin-whitening agents.
• Synonyms: ISCK03, ISCK-03, ISCK 03
• IUPAC Name: [4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide
• Canonical SMILES: O=S(N(C1=CC=C(C(C)(C)C)C=C1)C2=CC=C(N3C=CN=C3)C=C2)=O
• InChI: InChI=1S/C19H21N3O2S/c1-19(2,3)15-4-6-17(7-5-15)22(25(23)24)18-10-8-16(9-11-18)21-13-12-20-14-21/h4-14,25H,1-3H3
• InChI Key: YKRCYYGZFGRSAX-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 64.20; H, 5.96; N, 11.82; O, 9.00; S, 9.02
• Exact Mass: 355.1354
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).