CAS
152946-68-4 Purity
≥98%
152946-68-4 Purity
≥98%
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Hydroxyfasudil hydrochloride
CAS
155558-32-0
Catalog Number
ACM155558320
Category
Inhibitors
Molecular Weight
343.83
Molecular Formula
C14H18ClN3O3S
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Specification
Description
Hydroxyfasudil hydrochloride is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively.
Synonyms
1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine Hydrochloride;
5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone; HA1100 Hydrochloride;
5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone; HA1100 Hydrochloride;
Appearance
Off-White Solid
Blog
Rho-associated coiled-coil containing protein kinases (ROCKs), comprising ROCK1 and ROCK2 isoforms, are key serine/threonine kinases belonging to the AGC kinase family. They act as central regulators in various cellular processes such as cytoskeletal dynamics, cell proliferation, apoptosis, migration, and gene expression.
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