Hexaethylene glycol di-p-toluenesulfonate

• Catalog Number: ACM42749279-1
• Product Name: Hexaethylene glycol di-p-toluenesulfonate
• CAS: 42749-27-9
• Category: Heterocyclic Organic Compound
• Description: Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.
• Synonyms: HEG ditosylate, Hexaethylene glycol ditosylate
• IUPAC Name: 2-[2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
• Molecular Weight: 590.70
• Molecular Formula: C26H38O11S2
• Canonical SMILES: Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCOCCOS(=O)(=O)c2ccc(C)cc2
• InChI: 1S/C26H38O11S2/c1-23-3-7-25(8-4-23)38(27,28)36-21-19-34-17-15-32-13-11-31-12-14-33-16-18-35-20-22-37-39(29,30)26-9-5-24(2)6-10-26/h3-10H,11-22H2,1-2H3
• InChI Key: ZIZXHPCBPDNLDD-UHFFFAOYSA-N
• Boiling Point: 687.4ºC at 760 mmHg
• Flash Point: 369.5ºC
• Density: 1.227 g/mL at 25 °C
• Application: Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.
• Assay: >97%
• Exact Mass: 590.18600
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• H-Bond Acceptor: 11
• H-Bond Donor: 0
• MDL Number: MFCD00319275
• NACRES: NA.23
• PubChem ID: 329764834
• Quality Level: 100
• Refractive Index: n20/D 1.521