Glucagon Hydrochloride

• CAS: 16941-32-5
• Catalog Number: ALC-FP-16941325
• Category: Featured Products
• Molecular Weight: 3482.75
• Molecular Formula: C153H225N43O49S
• Appearance: White or almost white powder
• Cl: Max. 2.0%
• Insolubility: Insoluble in water
• Mass Spectrum: 3482.75±1
• Related Substances: Total Impurities ≤ 3.0%; Largest Single Impurity ≤ 1.0%
• Residual Solvent: Acetonitrile ≤ 410 ppm; Dichloromethane ≤ 600 ppm; N,N-Dimethylformamide ≤ 880 ppm
• Sample Lot No.: A24M0620x0619
• Water Content: Max. 10.0%

Case Study

Glucagon Hydrochloride for Bowel Relaxation in CT Colonography

MC de Haan, et al. European Journal of Radiology, 2012, 81(8), e910-e916.

This case study evaluates the experimental application of Glucagon Hydrochloride as a pharmacological bowel relaxant in CT colonography screening. In a prospective screening trial, participants received an intravenous bolus of 1 mg glucagon hydrochloride, administered immediately prior to colonic insufflation, primarily in cases where anticholinergic agents were contraindicated. Colonic distension was systematically assessed per anatomical segment using a standardized 4-point scoring system under both supine and prone imaging positions. Patient-reported burden and tolerability were collected via structured questionnaires two weeks post-procedure, enabling quantitative comparison of procedural discomfort. Statistical analysis employed propensity score matching to balance baseline characteristics, followed by stratified Wilcoxon-Mann-Whitney and Cochran-Mantel-Haenszel tests. The methodology demonstrates glucagon hydrochloride's practical utility as a smooth muscle relaxant facilitating colonic distension, while allowing controlled evaluation of imaging quality, patient burden, and side-effect profiles in clinical imaging workflows.