Fmoc-thioproline

• CAS: 133054-21-4
• Catalog Number: ACM133054214
• Category: Amino Acids
• Molecular Weight: 333.43
• Description: A building block for the introduction of thiaproline (Thz) during Fmoc SPPS. Thz has been employed as a masked cysteine residue to prevent self-ligation during native chemical ligation reactions (NCL) of peptide thioesters bearing an N-terminal Cys residue. Once ligation is complete, the N-terminal Cys residue of the resultant peptide is unmasked by ring-opening the Thz residue by treatment with methoxyamine, thereby enabling its subsequent ligation to another peptide thioester fragment.
• Synonyms: Fmoc-thioproline, Fmoc-thiaproline,Fmoc-thiazolidine-4-carboxylic acid
• InChI: 1S/C19H17NO4S/c21-18(22)17-10-25-11-20(17)19(23)24-9-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16-17H,9-11H2,(H,21,22)/t17-/m0/s1
• InChI Key: HUWNZLPLVVGCMO-KRWDZBQOSA-N
• Application: Peptide synthesis.
• Assay: ≥98% (TLC); ≥99.0% (HPLC)
• Form: powder
• Functional Group: Fmoc
• Quality Level: 200
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: 15-25℃