Fmoc-Hyp(tBu)-OH

• CAS: 122996-47-8
• Catalog Number: ACM122996478
• Category: Amino Acids
• Molecular Weight: 409.47
• Molecular Formula: C24H27NO5
• Description: Standard building block for introduction of hydroxyproline amino-acid residues by Fmoc SPPS.
• Synonyms: Fmoc-Hyp(tBu)-OH, N-α-Fmoc-O-t.-butyl-L-trans-4-hydroxyproline, Fmoc-(2S,4R)-(-)-4-t-butoxypyrrolidine-2-carboxylic acid
• InChI: 1S/C24H27NO5/c1-24(2,3)30-15-12-21(22(26)27)25(13-15)23(28)29-14-20-18-10-6-4-8-16(18)17-9-5-7-11-19(17)20/h4-11,15,20-21H,12-14H2,1-3H3,(H,26,27)/t15-,21+/m1/s1
• InChI Key: WPBXBYOKQUEIDW-VFNWGFHPSA-N
• Melting Point: 63℃
• Application: Peptide synthesis.
• Assay: ≥95.0% (acidimetric); ≥98% (TLC); ≥98.0% (HPLC)
• Form: powder
• Functional Group: hydroxyl
• MDL Number: MFCD00151930
• Quality Level: 200
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: 15-25℃
• Type: Unusual Amino Acids, Analogs of Proline

Synthetic Use

Downstream Synthesis Route 1

• 771-61-9
• 122996-47-8

• 147836-80-4

Reference: [1]Current Patent Assignee: DIEVINI HOPP BIOTECH HOLDING GMBH & CO. KG - WO2017/89607, 2017, A1
Location in patent: Paragraph 00131
[2]Franzyk, Henrik; Meldal, Morten; Paulsen, Hans; Bock, Klaus
[Journal of the Chemical Society. Perkin transactions I, 1995, # 22, p. 2883 - 2898]

* For details of the synthesis route, please refer to the original source to ensure accuracy.