Fmoc-(Dmb)Gly-OH

• CAS: 166881-42-1
• Catalog Number: ACM166881421
• Category: Amino Acids
• Molecular Weight: 447.48
• Description: Fmoc-(Dmb)Gly-OH is an excellent reagent for enhancing synthetic efficiency of glycine-containing peptides by Fmoc SPPS.Like the analogous Hmb derivative Fmoc-(FmocHmb)Gly-OH, the use of this derivative prevents aggregation during chain assemby, thereby leading to faster and more predictable acylation and deprotection reactions. Furthermore, it can prevent aspartimide formation when used to introduce a Gly immediately before an Asp residue and help promote cyclization of Gly-containing peptides. The analogous (Tmob)Gly derivative has been used by Bayer and colleagues to prepare a 64-residue transmembrane peptide in remarkable purity.
• Synonyms: Fmoc-(Dmb)Gly-OH, N-α-Fmoc-N-α-(2, 4-dimethoxybenzyl)-glycine
• InChI: 1S/C26H25NO6/c1-31-18-12-11-17(24(13-18)32-2)14-27(15-25(28)29)26(30)33-16-23-21-9-5-3-7-19(21)20-8-4-6-10-22(20)23/h3-13,23H,14-16H2,1-2H3,(H,28,29)
• InChI Key: UIDQSTVPYKMCEY-UHFFFAOYSA-N
• Application: Peptide synthesis.
• Assay: ≥94.0% (acidimetric); ≥98% (TLC); ≥99.0% (HPLC)
• Form: powder
• Functional Group: Fmoc
• MDL Number: MFCD08064316
• Quality Level: 200
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: -10 to -25℃