Fmoc-Cys(tBu)-OH

• CAS: 67436-13-9
• Catalog Number: ACM67436139
• Category: Amino Acids
• Molecular Weight: 399.5
• Description: The side-chain tBu group is stable to TFA and iodine oxidation. Treatment with MeSiCl3/PhSOPh removes t-Bu and cyclizes in one step without scrambling existing disulphide bonds. Removed with Hg(II) to give cysteinyl peptides.
• Synonyms: Fmoc-Cys(tBu)-OH, N-α-Fmoc-S-t.-butyl-L-cysteine
• InChI: 1S/C22H25NO4S/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)
• InChI Key: IXAYZHCPEYTWHW-UHFFFAOYSA-N
• Melting Point: 133-136℃
• Application: Peptide synthesis.
• Assay: ≥97.0% (acidimetric); ≥98% (TLC); ≥98.0% (HPLC)
• Form: powder
• Functional Group: thiol
• MDL Number: MFCD00037130
• Quality Level: 200
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: 2-30℃

Synthetic Use

Upstream Synthesis Route 1

• 28920-43-6
• 2481-09-6

• 67436-13-9

Reference: [1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985, p. 2057 - 2064

Upstream Synthesis Route 2

• 135273-01-7

• 67436-13-9

Reference: [1] Protein and Peptide Letters, 2014, vol. 21, # 12, p. 1257 - 1264

Upstream Synthesis Route 3

• 28920-43-6
• 2481-09-6

• 67436-13-9

Reference: [1]Journal of the Chemical Society. Perkin transactions I,1985,p. 2057 - 2064

Downstream Synthesis Route 1

• 35661-60-0
• 67436-13-9
• 115057-30-2
• 71989-31-6

• 50-56-6

Reference: [1] Tetrahedron Letters, 1987, vol. 28, # 46, p. 5651 - 5654

Downstream Synthesis Route 2

• 54714-11-3
• 67436-13-9

• 113534-23-9

Reference: [1]Liebigs Annalen der Chemie,1988,p. 437 - 440

Downstream Synthesis Route 3

• 68206-45-1
• 67436-13-9

• 82176-99-6

Reference: [1]Chemistry Letters,1982,p. 921 - 924

* For details of the synthesis route, please refer to the original source to ensure accuracy.