Ezetimibe Intermediate

• CAS: 189028-93-1
• Catalog Number: ACM189028931
• Category: Other Products
• Molecular Weight: 355.36
• Molecular Formula: C₂₀H₁₈FNO₄
• Synonyms: (4s)-3-[5-(4-fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone;3-[5-[(4-FLUOROPHENYL)-1-5-DIOXOPENTA]-YL-4-(S)-PHENYL OXNZOLIDINE-2-ONE;3-[5-(4-FLUOROPHENYL)-1,5-DIOXOPENTYL]-4-PHENYL-(4S)-2-OXAZOLIDINONE;2-OXAZOLIDINONE, 3-[5-(4-FLUOROPHENYL)-1,5-D
• Density: 1.288 g/cm³
• Appearance: Off-White Solid
• Application: Used for lowering cholesterol
• Assay: ≥99.0%
• Related Substances: lndividual impurities≤0.2%, total impurities≤0.5%
• Storage Conditions: Preserve in well closed containers
• Water Content: Not more than 0.5%

Synthetic Use

Upstream Synthesis Route 1

• 99395-88-7
• 149437-76-3

• 189028-93-1

Reference: [1] Patent: WO2010/71358, 2010, A2, . Location in patent: Page/Page column 14-15

Upstream Synthesis Route 2

• 58518-77-7
• 259529-54-9

• 189028-93-1

Reference: [1] Patent: CN105541742, 2016, A, . Location in patent: Paragraph 0059; 0060'0061

Upstream Synthesis Route 3

• 3282-30-2
• 149437-76-3
• 186343-35-1

• 189028-93-1

Reference: [1] Patent: US2008/287663, 2008, A1, . Location in patent: Page/Page column 23

Downstream Synthesis Route 1

• 189028-93-1

• 189028-95-3

Reference: [1]Patent: KR101491007,2015,B1 .Location in patent: Paragraph 0036; 0038

* For details of the synthesis route, please refer to the original source to ensure accuracy.