Carbomer

• CAS: 54182-57-9
• Catalog Number: ACM54182579
• Category: Other Products

Case Study

Carbomer-Based Hydrogel for the Localized Delivery of Cathelicidin-DM in Infected Wound Healing Applications

Wang G, et al. International Journal of Biological Macromolecules, 2025, 288, 38659.

Carbomer was employed as a polymeric matrix for the sustained delivery of the antimicrobial peptide cathelicidin-DM, aimed at enhancing wound healing in both infected and non-infected murine models. To prepare the hydrogel, 45 mg of carbomer was dispersed in 2.6 mL of distilled water and allowed to swell overnight at 4 °C. The resulting viscous dispersion was sterilized by autoclaving at 121 °C for 20 minutes. pH adjustment was carried out via dropwise addition of triethanolamine to induce gelation, forming a transparent carbomer hydrogel.
Cathelicidin-DM, dissolved in sterile water, was incorporated into the hydrogel at a final concentration of 200 μg/mL using vortex mixing. Final pH adjustment was performed to optimize gel stability and peptide compatibility. Rheological studies confirmed the formation of a stable three-dimensional polymeric network with favorable viscoelastic properties. In vivo experiments using full-thickness skin wounds infected with Staphylococcus aureus demonstrated accelerated re-epithelialization and reduced bacterial load upon treatment with the cathelicidin-DM-carbomer hydrogel.

Carbomer-Assisted Synthesis of CuO/Al₂O₃ Nanocomposite for Wettability Alteration in Carbonate Reservoirs

Jafarbeigi E, et al. Journal of Molecular Liquids, 2025, 425, 127270.

In this study, Carbomer was employed as a surface modifier in the synthesis of a CuO/Al₂O₃/Carbomer nanocomposite designed for enhanced oil recovery (EOR) in carbonate reservoirs. Initially, Al₂O₃ nanoparticles (<50 nm) were utilized as a base substrate, while CuO nanoparticles were synthesized via a co-precipitation method. The CuO/Al₂O₃ binary composite was subsequently functionalized with Carbomer through a multi-step incorporation process to enhance colloidal stability and interfacial activity.
BET results revealed a decrease in surface area after Carbomer functionalization, indicating successful surface coverage. Wettability alteration was evaluated by contact angle (CA) measurements on core samples treated with 400 ppm of the nanocomposite, yielding a superhydrophilic surface (CA = 32°). Interfacial tension (IFT) was also reduced significantly to 7.8 mN/m, confirming the composite's interfacial activity. Core flooding experiments demonstrated enhanced oil recovery, increasing by 26% and 21% in two distinct core samples. The integration of Carbomer enabled superior wettability alteration and dispersion stability, positioning the CuO/Al₂O₃/Carbomer nanocomposite as a promising hybrid EOR agent.