Aristolactam I

• CAS: 13395-02-3
• Catalog Number: ACM13395023
• Category: Inhibitors
• Molecular Weight: 293.27
• Molecular Formula: C17H11NO4
• Description: Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage.Aristololactam I (AL-I) directly injures renal proximal tubule cells, the cytotoxic potency of AL-I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase-3-dependent pathway.
• Synonyms: 8-Methoxy-6-aminophenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid 5,6-lactam
• IUPAC Name: 14-Methoxy-3,5-dioxa-10-azapentacyclo[9.7.1.02,6.08,19.013,18]nonadeca-1(18),2(6),7,11(19),12,14,16-heptaen-9-one
• Canonical SMILES: COC1=CC=CC2=C3C4=C(C=C21)NC(=O)C4=CC5=C3OCO5
• InChI: InChI=1S/C17H11NO4/c1-20-12-4-2-3-8-9(12)5-11-14-10(17(19)18-11)6-13-16(15(8)14)22-7-21-13/h2-6H,7H2,1H3,(H,18,19)
• InChI Key: MXOKGWUJNGEKBH-UHFFFAOYSA-N
• Boiling Point: 463.9±34.0 °C
• Melting Point: 319 °C
• Density: 1.49 g/ml
• Appearance: Powder
• Storage: 4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light).
• pKa: 12.36±0.20
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Source: Plantsother families