6-METHOXY-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE

• CAS: 58960-11-5
• Catalog Number: ACM58960115
• Category: Other Products
• Molecular Weight: 165.19
• Molecular Formula: C9H11NO2
• Synonyms: AKOS BC-1148;6-METHOXY-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE;6-METHOXY-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE
• IUPAC Name: 6-methoxy-3,4-dihydro-2H-1,4-benzoxazine
• SMILES: COC1=CC2=C(C=C1)OCCN2
• InChI Key: XLJYIYIBJUWRLF-UHFFFAOYSA-N
• Boiling Point: 279.543ºC at 760 mmHg
• Flash Point: 106.01ºC
• Density: 1.121g/cm³
• Exact Mass: 165.07900
• H-Bond Acceptor: 3
• H-Bond Donor: 1

Synthetic Use

Upstream Synthesis Route 1

• 5023-12-1

• 58960-11-5

Reference: [1]Vermeulen, Erik S; van Smeden, Marjan; Schmidt, Anne W; Sprouse, Jeffrey S; Wikstroem, Hakan V; Grol, Cor J
[Journal of medicinal chemistry, 2004, vol. 47, # 22, p. 5451 - 5466]

Upstream Synthesis Route 2

• 20734-76-3
• 106-93-4

• 58960-11-5

Reference: [1]Mizar, Pushpak; Myrboh, Bekington
[Tetrahedron Letters, 2006, vol. 47, # 44, p. 7823 - 7826]
[2]Current Patent Assignee: WUXI APPTEC CO., LTD. - EP3848371, 2021, A1
Location in patent: Paragraph 0102-0103

Downstream Synthesis Route 1

• 58960-11-5

• 26021-57-8

Reference: [1] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 380 - 396

Downstream Synthesis Route 2

• 58960-11-5
• 79-04-9

• 793672-19-2

Reference: [1]Vermeulen, Erik S; van Smeden, Marjan; Schmidt, Anne W; Sprouse, Jeffrey S; Wikstroem, Hakan V; Grol, Cor J
[Journal of medicinal chemistry, 2004, vol. 47, # 22, p. 5451 - 5466]

* For details of the synthesis route, please refer to the original source to ensure accuracy.