5,7-Diiodo-8-hydroxyquinoline

• CAS: 83-73-8
• Catalog Number: ACM83738
• Category: Quinolines
• Molecular Weight: 396.95g/mol
• Molecular Formula: C9H5I2NO
• IUPAC Name: 5,7-diiodoquinolin-8-ol
• Canonical SMILES: C1=CC2=C(C(=C(C=C2I)I)O)N=C1
• InChI: InChI=1S/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
• InChI Key: UXZFQZANDVDGMM-UHFFFAOYSA-N
• Melting Point: 210.0 °C;MP 200-215 °C WITH EXTENSIVE DECOMP
• Solubility: ALMOST INSOL IN WATER; SPARINGLY SOL IN ALCOHOL, ETHER, ACETONE; SOL IN HOT PYRIDINE & HOT DIOXANE
• Appearance: Yellow to Tan; Powder or Crystals
• Application: 5,7-Diiodo-8-hydroxyquinoline serves primarily as an amoebicidal agent utilized in the treatment of infections such as amoebiasis and balantidiasis, which are caused by protozoa. It is recognized as the preferred medication for addressing asymptomatic or moderate forms of amoebiasis. This compound plays multiple roles, functioning as an antiamoebic, antibacterial, antiseptic, and antiprotozoal agent. While it is effective for treating both acute and chronic intestinal amebiasis, it is not suitable for treating extraintestinal diseases. Notably, due to its relatively high risk of causing optic neuropathy, it is not recommended for routine use in managing traveler's diarrhea. This yellowish to tan, light-sensitive, microcrystalline substance is also known by other names such as 5,7-diiodo-8-quinolinol, diiodohydroxyquin, Yodoxin, Diodoquin, and Diquinol.
• Color/Form: CRYSTALS FROM XYLENE; MEDICINAL GRADE IS YELLOWISH-BROWN POWDER;ABOVE 150 DEG, SUBLIMATES OF NEEDLES, PRISMS & RODS; ABOVE 200 DEG BROWN DROPS; MELT TURNS DARK-BROWN;LIGHT YELLOWISH TO TAN, MICROCRYSTALLINE POWDER
• Complexity: 191
• Covalently-Bonded Unit Count: 1
• EC Number: 201-497-9
• Exact Mass: 396.84606g/mol
• Formal Charge: 0
• H-Bond Acceptor: 2
• H-Bond Donor: 1
• Heavy Atom Count: 13
• Monoisotopic Mass: 396.84606g/mol
• NSC Number: 757077;8704
• Odor: ODORLESS OR NEARLY SO
• Rotatable Bond Count: 0
• Stability: STABLE IN AIR
• UNII: 63W7IE88K8
• XLogP3: 3.1