4-(Methylamino)-2-(methylthio)pyrimidine-5-carboxylic Acid Ethyl Ester

• CAS: 76360-82-2
• Catalog Number: ACM76360822
• Category: Other Products
• Molecular Weight: 227.28
• Molecular Formula: C9H13N3O2S
• Synonyms: 4-Methylamino-2-methylthiopyrimidine-5-carboxylic Acid Ethyl Ester; Ethyl 4-(Methylamino)-2-(methylthio)pyrimidine-5-carboxylate; NSC 165300
• Appearance: White Solid

Synthetic Use

Upstream Synthesis Route 1

• 5909-24-0
• 74-89-5

• 76360-82-2

Reference: [1] Patent: WO2014/144737, 2014, A1, . Location in patent: Paragraph 00719

Upstream Synthesis Route 2

• 5909-24-0

• 76360-82-2

Reference: [1] Patent: US2003/171584, 2003, A1,

Upstream Synthesis Route 3

• 5909-24-0
• 593-51-1

• 76360-82-2

Reference: [1] Journal of Medicinal Chemistry, 2017, vol. 60, # 5, p. 1793 - 1816
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 5, p. 1984 - 2004
[3] Patent: WO2011/75616, 2011, A1, . Location in patent: Page/Page column 62

Downstream Synthesis Route 1

• 76360-82-2

• 17759-30-7

Reference: [1]Patent: WO2018/213219,2018,A1 .Location in patent: Paragraph 0053-0054; 0006; 0007

Downstream Synthesis Route 2

• 76360-82-2

• 863028-98-2

Reference: [1]Hisamichi, Hiroyuki; Naito, Ryo; Toyoshima, Akira; Kawano, Noriyuki; Ichikawa, Atsushi; Orita, Akiko; Orita, Masaya; Hamada, Noritaka; Takeuchi, Makoto; Ohta, Mitsuaki; Tsukamoto, Shin-Ichi
[Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 16, p. 4936 - 4951]
[2]Liang, Xiaofei; Liu, Xiaochuan; Wang, Beilei; Zou, Fengming; Wang, Aoli; Qi, Shuang; Chen, Cheng; Zhao, Zheng; Wang, Wenchao; Qi, Ziping; Lv, Fengchao; Hu, Zhenquan; Wang, Li; Zhang, Shanchun; Liu, Qingsong; Liu, Jing
[Journal of Medicinal Chemistry, 2016, vol. 59, # 5, p. 1984 - 2004]
[3]Liang, Xiaofei; Lv, Fengchao; Wang, Beilei; Yu, Kailin; Wu, Hong; Qi, Ziping; Jiang, Zongru; Chen, Cheng; Wang, Aoli; Miao, Weili; Wang, Wenchao; Hu, Zhenquan; Liu, Juan; Liu, Xiaochuan; Zhao, Zheng; Wang, Li; Zhang, Shanchuan; Ye, Zi; Wang, Chu; Ren, Tao; Wang, Yinsheng; Liu, Qingsong; Liu, Jing
[Journal of Medicinal Chemistry, 2017, vol. 60, # 5, p. 1793 - 1816]
[4]Current Patent Assignee: THE MCCLAY FOUNDATION - WO2015/19037, 2015, A1
Location in patent: Page/Page column 88

Downstream Synthesis Route 3

• 76360-82-2

• 185039-89-8

Reference: [1]Journal of Medicinal Chemistry,1998,vol. 41,p. 3276 - 3292

* For details of the synthesis route, please refer to the original source to ensure accuracy.