3-(3-triethoxysilylpropyl)oxolane-2,5-dione

• CAS: 93642-68-3
• Catalog Number: ACM93642683-6
• Category: Main Products
• Molecular Weight: 304.41g/mol
• Molecular Formula: C13H24O6Si
• Synonyms: 3-(TRIETHOXYSILYL)PROPYLSUCCINIC ANHYDRIDE
• IUPAC Name: 3-(3-triethoxysilylpropyl)oxolane-2,5-dione
• SMILES: CCO[Si](CCCC1CC(=O)OC1=O)(OCC)OCC
• InChI: InChI=1S/C13H24O6Si/c1-4-16-20(17-5-2,18-6-3)9-7-8-11-10-12(14)19-13(11)15/h11H,4-10H2,1-3H3
• InChI Key: GXDMUOPCQNLBCZ-UHFFFAOYSA-N
• Appearance: Colourless to yellow to tan liquid
• Complexity: 316
• Covalently-Bonded Unit Count: 1
• EC Number: 297-566-6
• Exact Mass: 304.134215g/mol
• Formal Charge: 0
• H-Bond Acceptor: 6
• H-Bond Donor: 0
• Heavy Atom Count: 20
• Monoisotopic Mass: 304.134215g/mol
• Rotatable Bond Count: 10

Case Study

3-(3-Triethoxysilylpropyl)oxolane-2,5-dione as Silanization Agent for Fiber Optic Biosensor Surface Modification

Chen, Ling, et al. 18th International Conference on Optical Communications and Networks (ICOCN). IEEE, 2019.

3-(3-Triethoxysilylpropyl)oxolane-2,5-dione serves as a key silanization reagent for surface functionalization of tapered singlemode-no core-singlemode (SNS) fiber biosensors, enabling stable covalent immobilization of antibodies for high-sensitivity Staphylococcus aureus detection.
Modification Protocol: The tapered SNS fiber (taper waist diameter 10.2 μm) was cleaned with ethanolic KOH solution, then silanized with 3-(3-triethoxysilylpropyl)oxolane-2,5-dione for 4 hours. Its anhydride group hydrolyzed spontaneously to carboxyl groups, followed by activation with EDC/NHSS. Pig IgG antibodies were immobilized, and BSA was used to block non-specific binding sites.
Performance Evaluation: This silane reagent efficiently introduced reactive carboxyl groups onto the fiber surface, ensuring stable antibody conjugation and reducing non-specific biofouling. The functionalized biosensor reached a refractive index sensitivity of 1127.3 nm/RIU and achieved a 1.1 nm wavelength blue shift toward S. aureus at 10¹ CFU/mL, realizing ultra-sensitive detection of foodborne pathogens.