Nanavaty N, Lin L, Hinckley S H, et al.
Tau Protein: Methods and Protocols, 2017: 101-111.Alzheimer’s disease is characterized in part by the intracellular misfolding and aggregation of tau protein. The aggregates, which range in size from small oligomers to large flaments, are markers for disease diag nosis and staging, potential vectors for disease propagation, and candidate sources of neurotoxicity. Here, the author present protocols for synthesizing large tau aggregates characterized by flamentous morphology and cross-β-sheet structure from monomeric full-length tau precursors in vitro. Read More