Esomeprazole

• Catalog Number: ACM119141887
• Product Name: Esomeprazole
• CAS: 119141-88-7
• Category: Main Products
• Synonyms: Esomeprazole(Na, Mg);(5-methoxy-1H-benzimidazol-2-yl)[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfoniumolate;(S)-Esomeprazole;Esomeprazole(Mg);5-Methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2- pyridinyl)methyl)sulfinyl)-1H-benzimidazole;6-Methoxy-2-[(R)-(4-methoxy-3,5-dimethyl-pyridin-2-yl)methylsulfinyl]-1H-benzoimidazole;Esomeprazole;EsoMeprazole EC Pellets 22%
• IUPAC Name: 6-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole
• Molecular Weight: 345.42
• Molecular Formula: C₁₇H₁₉N₃O₃S
• Canonical SMILES: CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC
• InChI Key: SUBDBMMJDZJVOS-DEOSSOPVSA-N
• Boiling Point: 600ºC at 760mmHg
• Flash Point: 316.7ºC
• Density: 1.37g/cm³
• Exact Mass: 345.11500

Custom Q&A

What is the molecular formula of esomeprazole?

The molecular formula of esomeprazole is C17H19N3O3S.

What are the synonyms for esomeprazole?

The synonyms for esomeprazole include (S)-Omeprazole, (S)-(-)-Omeprazole, (-)-Omeprazole, and 119141-88-7.

What is the molecular weight of esomeprazole?

The molecular weight of esomeprazole is 345.4 g/mol.

What is the role of esomeprazole in the body?

Esomeprazole has multiple roles in the body, including being an inhibitor of gastric acid secretion, histamine antagonist, and an anti-ulcer drug.

What conditions is esomeprazole used for?

Esomeprazole is used for the treatment of gastro-oesophageal reflux disease (GERD), dyspepsia, peptic ulcer disease, and Zollinger-Ellison syndrome.

What is the brand name of esomeprazole?

The brand name of esomeprazole is Nexium.

What class of medication does esomeprazole belong to?

Esomeprazole belongs to the proton pump inhibitor (PPI) class of medications.

How does esomeprazole work to reduce stomach acid secretion?

Esomeprazole works by covalently binding to sulfhydryl groups of cysteines found on the (H+, K+)-ATPase enzyme at the secretory surface of gastric parietal cells, leading to inhibition of both basal and stimulated gastric acid secretion.

Are there any differences between esomeprazole and its racemate, omeprazole?

Esomeprazole is the S-isomer of omeprazole, which is a racemate of the S- and R-enantiomer. In vitro studies have shown that esomeprazole exhibits similar efficacy in inhibiting acid secretion compared to omeprazole.

What is the potential association of esomeprazole with cardiovascular events?

PPIs, including esomeprazole, have been associated with an increased risk of cardiovascular events in patients with unstable coronary syndromes. This may be due to the inhibition of dimethylarginine dimethylaminohydrolase (DDAH) activity, leading to an accumulation of the nitric oxide synthase inhibitor ADMA.