Disperse blue 124

• CAS: 61951-51-7
• Catalog Number: ACM61951517
• Category: Main Products
• Molecular Weight: 377.42
• Molecular Formula: C16H19N5O4S
• Synonyms: 2-(N-Ethyl-4-((5-nitrothiazol-2-yl)azo)-m-toluidino)ethyl acetate
• Appearance: Dark grey powder

Case Study

Evaluating the Role of Impurities in Disperse Blue 124 Contact Allergy Diagnosis

Ryberg, Kristina, et al. Contact Dermatitis 60.5 (2009): 270-278.

Disperse Blue (DB) 106 and DB 124 are recognized as significant contact sensitizers among textile dyes, frequently identified among the most common disperse dye allergens. Due to their allergenic potential and structural similarity (leading to frequent co-reactivity), they are often recommended as screening allergens for textile dye dermatitis. This investigation aimed to determine the significance of impurities present in commercial DB 106 and DB 124 patch test preparations concerning the diagnosis of contact allergy to these dyes.
Twenty-one patients diagnosed with contact allergy to DB 106 and/or DB 124 underwent patch testing with dilution series of commercially available and purified samples of DB 106 and DB 124.
Key Findings
· TLC Strip Reactivity: Positive reactions occurred to TLC strips of commercial DB 106 in 13 out of 21 patients and to DB 124 strips in 12 out of 18 patients tested.
· Reactivity to Impurities: Among the patients reacting to the TLC strips, 4 out of 13 (DB 106) and 5 out of 12 (DB 124) reacted only to spots corresponding to impurities, not to the main spot representing the dye itself.
· Purified vs. Commercial Dye Reactivity: Dilution series testing revealed that purified DB 106 elicited positive reactions in 10 patients, while the commercial DB 106 preparation elicited reactions in 16 patients. Similarly, purified DB 124 elicited reactions in 10 patients, whereas the commercial DB 124 preparation elicited reactions in 15 patients.

Custom Q&A

What is the molecular formula of Disperse Blue 124?

The molecular formula of Disperse Blue 124 is C16H19N5O4S.

When was Disperse Blue 124 first created and modified according to the reference?

Disperse Blue 124 was first created on August 8, 2005, and last modified on December 30, 2023.

What is the role of Disperse Blue 124 as mentioned in the reference?

Disperse Blue 124 has a role as a dye, a hapten, and an allergen.

What is the IUPAC Name of Disperse Blue 124?

The IUPAC Name of Disperse Blue 124 is 2-[N-ethyl-3-methyl-4-[(5-nitro-1,3-thiazol-2-yl)diazenyl]anilino]ethyl acetate.

What is the InChIKey of Disperse Blue 124?

The InChIKey of Disperse Blue 124 is HMAJVAFLGGPIPN-UHFFFAOYSA-N.

What is the CAS number for Disperse Blue 124?

The CAS number for Disperse Blue 124 is 15141-18-1 and 61951-51-7.

What is the molecular weight of Disperse Blue 124?

The molecular weight of Disperse Blue 124 is 377.4 g/mol.

How many hydrogen bond acceptors does Disperse Blue 124 have?

Disperse Blue 124 has 9 hydrogen bond acceptors.

How many rotatable bond counts does Disperse Blue 124 have?

Disperse Blue 124 has 8 rotatable bond counts.

What is the topological polar surface area of Disperse Blue 124?

The topological polar surface area of Disperse Blue 124 is 141 Å^2.