Chiong HA1, Pham QN, Daugulis O.
J Am Chem Soc. 2007 Aug 15;129(32):9879-84. Epub 2007 Jul 25.Two new palladium-catalyzed methods for the direct ortho-arylation of free benzoic acids have been developed. The first method employs stoichiometric silver acetate for iodide removal, aryl iodide as the coupling partner, and acetic acid solvent. This method is applicable to the arylation of electron-rich to moderately electron-poor benzoic acids and tolerates chloride and bromide substituents on b ... Read More