5'-O-[Bis-(4-methoxyphenyl)phenylmethyl]-2'-O-[(tert-butyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)guanosine

Name: 5'-O-[Bis-(4-methoxyphenyl)phenylmethyl]-2'-O-[(tert-butyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)guanosine
SKU: ACM81279392
Rating: 5 (1 reviews)

CAS

81279-39-2

Catalog Number

ACM81279392

Category

Other Products

Molecular Weight

769.957840 [g/mol]

Molecular Formula

C41H51N5O8Si

COA MSDS SDS Spec Sheet

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Specification

Synonyms

81279-39-2, N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, SureCN1582220, CTK8B4325, ANW-44696, AKOS015999126, 5-O-DMT-2-O-iBu-N-Bz-Guanosine, AK-54689, KB-258278

IUPAC Name

N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-6-oxo-3H-purin-2-yl]-2-methylpropanamide

SMILES

CC(C)C(=O)NC1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O)O[Si](C)(C)C(C)(C)C

InChI Key

JMCNKJFOIJGYRG-CJEGOSRCSA-N

Density

1.25

Exact Mass

769.35100

H-Bond Acceptor

H-Bond Donor

Upstream Synthesis Route 1

18162-48-6
81246-83-5

81279-39-2

Reference: [1] Organic Letters, 2013, vol. 15, # 18, p. 4710 - 4713

Upstream Synthesis Route 2

18162-48-6
81246-83-5

81279-39-2
81256-89-5

Reference: [1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 12, p. 4485 - 4497
[2] Canadian Journal of Chemistry, 1982, vol. 60, p. 111 - 120
[3] Patent: US2011/86813, 2011, A1, . Location in patent: Page/Page column 31

Upstream Synthesis Route 3

40615-36-9
182007-86-9

81279-39-2

Reference: [1] Nucleosides, nucleotides and nucleic acids, 2003, vol. 22, # 5-8, p. 1007 - 1009
[2] Tetrahedron Letters, 2002, vol. 43, # 11, p. 1983 - 1985

Upstream Synthesis Route 4

18162-48-6
81246-83-5

81279-39-2
81256-89-5

Reference: [1]Bioorganic and Medicinal Chemistry,2010,vol. 18,p. 4485 - 4497
[2]Canadian Journal of Chemistry,1982,vol. 60,p. 111 - 120
[3]Patent: US2011/86813,2011,A1 .Location in patent: Page/Page column 31

Downstream Synthesis Route 1

81279-39-2
109-78-4
772-79-2

81279-43-8

Reference: [1]Canadian Journal of Chemistry,1982,vol. 60,p. 111 - 120

* For details of the synthesis route, please refer to the original source to ensure accuracy.

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