1,4-Dichlorophthalazine

Name: 1,4-Dichlorophthalazine
SKU: ACM4752107
Rating: 5 (1 reviews)

CAS

4752-10-7

Catalog Number

ACM4752107

Category

Other Products

Molecular Weight

199.04

Molecular Formula

C₈H₄Cl₂N₂

COA MSDS SDS Spec Sheet

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Specification

Synonyms

1,4-DICHLOROPHTHALAZINE;1,4-Dichlorophtalazine

Density

1.486 g/cm³

Appearance

White to tan crystals to powder

Upstream Synthesis Route 1

1445-69-8

4752-10-7

Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 4, p. 1236 - 1238

Upstream Synthesis Route 2

1445-69-8

4752-10-7

Reference: [1] Organic and Biomolecular Chemistry, 2012, vol. 10, # 36, p. 7313 - 7320
[2] Australian Journal of Chemistry, 1985, vol. 38, # 11, p. 1685 - 1691
[3] Patent: WO2003/99274, 2003, A1, . Location in patent: Page 277-278

Upstream Synthesis Route 3

253-52-1

5784-45-2
4752-10-7

Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 14, p. 3300 - 3306

Downstream Synthesis Route 1

4752-10-7
62-53-3

87166-49-2

Reference: [1]Medda, Federico; Sells, Earlphia; Chang, Hui-Hua; Dietrich, Justin; Chappeta, Shashi; Smith, Breland; Gokhale, Vijay; Meuillet, Emmanuelle J.; Hulme, Christopher
[Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 2, p. 528 - 531]
[2]Bollenbach, Maud; Lugnier, Claire; Kremer, Mélanie; Salvat, Eric; Megat, Salim; Bihel, Frédéric; Bourguignon, Jean-Jacques; Barrot, Michel; Schmitt, Martine
[European Journal of Medicinal Chemistry, 2019, vol. 177, p. 269 - 290]
[3]Haworth; Robinson
[Journal of the Chemical Society, 1948, p. 777,781]
[4]Piatnitski, Evgueni L.; Duncton, Matthew A. J.; Kiselyov, Alexander S.; Katoch-Rouse, Reeti; Sherman, Dan; Milligan, Daniel L.; Balagtas, Chris; Wong, Wai C.; Kawakami, Joel; Doody, Jacqueline F.
[Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 21, p. 4696 - 4698]

Downstream Synthesis Route 2

4752-10-7
88-99-3

2257-69-4

Reference: [1]Drew; Hatt
[Journal of the Chemical Society, 1937, p. 16,25]
[2]Drew; Hatt
[Journal of the Chemical Society, 1937, p. 16,25]

Downstream Synthesis Route 3

4752-10-7

2257-69-4

Reference: [1]Lu, Dong; Liu, Jianan; Zhang, Yunzhe; Liu, Feifei; Zeng, Limin; Peng, Runze; Yang, Li; Ying, Huazhou; Tang, Wei; Chen, Wuhong; Zuo, Jianping; Tong, Xiankun; Liu, Tao; Hu, Youhong
[European Journal of Medicinal Chemistry, 2018, vol. 145, p. 328 - 337]
[2]Current Patent Assignee: Shanghai Institute of Materia Medica (in: CAS); CHINESE ACADEMY OF SCIENCES - CN109134429, 2019, A
Location in patent: Paragraph 0106; 0108; 0109; 0110
[3]Current Patent Assignee: CHINESE ACADEMY OF SCIENCES; Shanghai Institute of Materia Medica (in: CAS) - CN109384727, 2019, A
Location in patent: Paragraph 0092-0094
[4]Haworth; Robinson
[Journal of the Chemical Society, 1948, p. 777,781]
[5]Current Patent Assignee: Shanghai Institute of Materia Medica (in: CAS); CHINESE ACADEMY OF SCIENCES - CN112125881, 2020, A
Location in patent: Paragraph 0098-0101

* For details of the synthesis route, please refer to the original source to ensure accuracy.

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