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Structure

4-Oxo-L-proline

CAS
4347-18-6
Catalog Number
ACM4347186
Category
Other Products
Molecular Weight
129.11398
Molecular Formula
C5H7NO3

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Specification

Synonyms
4-oxo-L-proline;(S)-4-Oxo-pyrrolidine-2-carboxylic acid;Einecs 224-409-0
IUPAC Name
(2S)-4-oxopyrrolidine-2-carboxylic acid
Canonical SMILES
C1C(NCC1=O)C(=O)O
InChI Key
HFXAFXVXPMUQCQ-BYPYZUCNSA-N
Boiling Point
341.8ºC at 760 mmHg
Flash Point
160.5ºC
Density
1.38 g/cm1.38 g/cm³
EC Number
224-409-0
Exact Mass
129.04300
H-Bond Acceptor
4
H-Bond Donor
2
Publications

Bacterial Alkaloid Biosynthesis: Structural Diversity via a Minimalistic Nonribosomal Peptide Synthetase

Klapper M, Braga D, Lackner G, et al
Cell chemical biology, 2018, 25(6): 659-665. e9
Chemical and biochemical analyses of one of the most basic nonribosomal peptide synthetases (NRPS) from a Pseudomonas fluorescens strain revealed its striking plasticity. Determination of the potential substrate scope enabled us to anticipate novel secondary metabolites that could subsequently be isolated and tested for their bioactivities. Detailed analyses of the monomodular pyreudione synthetase showed that the biosynthesis of the bacterial pyreudione alkaloids does not require additional biosynthetic enzymes. Heterologous expression of a similar and functional, yet cryptic, NRPS of Pseudom...

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