6-FAM

• CAS: 3301-79-9
• Catalog Number: ACM3301799-1
• Category: Fluorescein Fluorophores
• Molecular Weight: 376.32
• Molecular Formula: C21H12O7
• Synonyms: 6-Carboxyfluorescein
• IUPAC Name: 3',6'-dihydroxy-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-carboxylicacid
• SMILES: C1=CC2=C(C=C1C(=O)O)C3(C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O)OC2=O
• InChI: InChI=1S/C21H12O7/c22-11-2-5-14-17(8-11)27-18-9-12(23)3-6-15(18)21(14)16-7-10(19(24)25)1-4-13(16)20(26)28-21/h1-9,22-23H,(H,24,25)
• InChI Key: BZTDTCNHAFUJOG-UHFFFAOYSA-N
• Boiling Point: 736.4 ± 60.0 °C
• Melting Point: >300 °C
• Density: 1.73 ± 0.1 g/ml
• Appearance: Yellow powder
• Storage: -20 °C in the dark
• Emission Maximum: 517 nm
• Excitation Maximum: 495 nm

Synthetic Use

Upstream Synthesis Route 1

• 108-46-3
• 552-30-7

• 3301-79-9
• 76823-03-5

Reference: [1] Russian Journal of General Chemistry, 1995, vol. 65, # 3.2, p. 454 - 456

Upstream Synthesis Route 2

• 100-44-7
• 108-46-3
• 552-30-7

• 3301-79-9
• 76823-03-5

Reference: [1] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2016, vol. 169, p. 66 - 71

Upstream Synthesis Route 3

• 108-46-3
• 552-30-7

• 3301-79-9
• 76823-03-5

Reference: [1]Russian Journal of General Chemistry,1995,vol. 65,p. 454 - 456
Zhurnal Obshchei Khimii,1995,vol. 65,p. 511 - 513
[2]Organic Letters,2009,vol. 11,p. 2499 - 2502
[3]Angewandte Chemie - International Edition,2012,vol. 51,p. 9441 - 9447
Angew. Chem.,2012,vol. 124,p. 9577 - 9783,7
[4]Chemical Communications,2014,vol. 50,p. 12761 - 12764

Downstream Synthesis Route 1

• 6066-82-6
• 3301-79-9

• 92557-81-8

Reference: [1]Tetrahedron,1998,vol. 54,p. 3093 - 3112

* For details of the synthesis route, please refer to the original source to ensure accuracy.