What is the molecular formula of 4-Aza-DL-leucine dihydrochloride?
The molecular formula is C5H14Cl2N2O2.
What are the synonyms for 4-Aza-DL-leucine dihydrochloride?
The synonyms are 34064-27-2, 102029-69-6, 2-Amino-3-(dimethylamino)propanoic acid dihydrochloride, and Dap(me)2 2HCl.
What is the molecular weight of 4-Aza-DL-leucine dihydrochloride?
The molecular weight is 205.08 g/mol.
What is the parent compound of 4-Aza-DL-leucine dihydrochloride?
The parent compound is Azaleucine (CID 303570).
What are the component compounds of 4-Aza-DL-leucine dihydrochloride?
The component compounds are Azaleucine (CID 303570) and Hydrochloric Acid (CID 313).
When was 4-Aza-DL-leucine dihydrochloride created?
It was created on August 8, 2009.
When was 4-Aza-DL-leucine dihydrochloride last modified?
It was last modified on October 21, 2023.
What is the IUPAC name of 4-Aza-DL-leucine dihydrochloride?
The IUPAC name is 2-amino-3-(dimethylamino)propanoic acid;dihydrochloride.
What is the InChI of 4-Aza-DL-leucine dihydrochloride?
The InChI is InChI=1S/C5H12N2O2.2ClH/c1-7(2)3-4(6)5(8)9;;/h4H,3,6H2,1-2H3,(H,8,9);2*1H.
What is the CAS number of 4-Aza-DL-leucine dihydrochloride?
The CAS number is 102029-69-6.
4-Aza-Dl-Leucine Dihydrochloride as A Resistance Screening Compound in Metabolic Engineering
Su H, et al Scientific Reports, 2016, 6(1), 39543.
4-Aza-dl-leucine dihydrochloride (AZL) is a leucine analog that can be used as a resistance screening compound in metabolic engineering studies to obtain compounds with high 3-methyl-1-butanol Yields feedback inhibition of AHAS or IPMS mutants. AZL has been previously used against Bacillus subtilis, Escherichia coli, and Salmonella typhimurium to identify drug-resistant strains. Mutagenicity Experiment · Yeast cells were adjusted to pH 6.0 with phosphate buffer solution. The chemical mutagen 1-methyl-3-nitro-1-nitroso-guanidine (NTG) was dissolved in 1 mL of acetone and added to each sample (5 mL). · Adjust the final concentration of NTG to 500 μg/mL, and then incubate in a constant temperature shaker at 30°C for 15 min. The mutant cells were then collected by centrifugation and washed three times with distilled water. · 200 μL of resuspended mutant cells were inoculated on yeast nitrogen base (YNB) solid medium containing 20 mg/mL 4-Aza-dl-leucine dihydrochloride (AZL), and then cultured at a constant temperature of 30°C. Incubate in the box for about three days until colonies appear. · Finally, fermentation experiments were conducted using fermented glucose and duckweed hydrolyzate, and the auxotrophic strain with the highest C4~C5 alcohol concentration was identified.
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