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Home > Product > Boronic Compounds > Boronic Acids > 2-(Trifluoromethoxy)phenylboronic acid

2-(Trifluoromethoxy)phenylboronic acid

Catalog Number
ACM175676650
Product Name
2-(Trifluoromethoxy)phenylboronic acid
Structure
CAS Number
175676-65-0
Synonyms
AKOS BRN-0449;2-(TRIFLUOROMETHOXY)BENZENEBORONIC ACID;2-(TRIFLUORMETHOXY)PHENYLBORONIC ACID;2-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID;RARECHEM AH PB 0077;O-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID;2-(Trifluoromethoxy)Phenylboro;2-(Trifluoromethoxy)phenylboronic
Molecular Formula
C7H6BF3O3
Molecular Weight
205.93
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1Boronic acid-containing aminopyridine- and aminopyrimidinecarboxamide CXCR1/2 antagonists: Optimization of aqueous solubility and oral bioavailability.

Schuler AD1, Engles CA2, Maeda DY2, Quinn MT3, Kirpotina LN3, Wicomb WN4, Mason SN5, Auten RL5, Zebala JA2.

Bioorg Med Chem Lett. 2015 Sep 15;25(18):3793-7. doi: 10.1016/j.bmcl.2015.07.090. Epub 2015 Jul 30.

The chemokine receptors CXCR1 and CXCR2 are important pharmaceutical targets due to their key roles in inflammatory diseases and cancer progression. We have previously identified 2-[5-(4-fluoro-phenylcarbamoyl)-pyridin-2-ylsulfanylmethyl]-phenylboronic acid (SX-517) and 6-(2-boronic acid-5-trifluoromethoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide (SX-576) as potent non-competitive boronic acid-containing CXCR1/2 antagonists. Read More

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Tel:1-201-478-8534
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Address: 2200 Smithtown Avenue, Room 1 Ronkonkoma, NY 11779-7329 USA