Nishihara K1, Huang R2, Zhao J2, Shahane SA2, Witt KL3, Smith-Roe SL3, Tice RR3, Takeda S4, Xia M5.
Mutagenesis. 2016 Jan;31(1):69-81. doi: 10.1093/mutage/gev055. Epub 2015 Aug 4.DNA repair pathways play a critical role in maintaining cellular homeostasis by repairing DNA damage induced by endogenous processes and xenobiotics, including environmental chemicals. Induction of DNA damage may lead to genomic instability, disruption of cellular homeostasis and potentially tumours. Isogenic chicken DT40 B-lymphocyte cell lines deficient in DNA repair pathways can be used to identify genotoxic compounds and aid in characterising the nature of the induced DNA damage. Read More