Fu DJ1, Zhang L1, Song J1, Mao RW1, Zhao RH1, Liu YC1, Hou YH1, Li JH1, Yang JJ1, Jin CY1, Li P1, Zi XL2, Liu HM1, Zhang SY3, Zhang YB4.
Eur J Med Chem. 2016 Dec 14;127:87-99. doi: 10.1016/j.ejmech.2016.12.027. [Epub ahead of print]A series of novel formononetin-dithiocarbamate derivatives were designed, synthesized and evaluated for antiproliferative activity against three selected cancer cell line (MGC-803, EC-109, PC-3). The first structure-activity relationship (SAR) for this formononetin-dithiocarbamate scaffold is explored in this report with evaluation of 14 variants of the structural class. Among these analogues, tert-butyl 4-(((3-((3-(4-methoxyphenyl)-4-oxo-4H-chromen-7-yl)oxy)propyl)thio)carbonothioyl)piperazine-1-carboxylate (8i) showed the best inhibitory activity against PC-3 cells (IC50 = 1. Read More