LoPachin RM1, Gavin T2.
Neurosci Lett. 2015 Jun 2;596:78-83. doi: 10.1016/j.neulet.2014.08.054. Epub 2014 Sep 16.2,5-Hexanedione (HD) and acrylamide (ACR) are considered to be prototypical among chemical toxicants that cause central-peripheral axonopathies characterized by distal axon swelling and degeneration. Because the demise of distal regions was assumed to be causally related to the onset of neurotoxicity, substantial effort was devoted to deciphering the respective mechanisms. Continued research, however, revealed that expression of the presumed hallmark morphological features was dependent upon the daily rate of toxicant exposure. Read More