Product Name
5-Aminosalicylic acid
Description
5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.
Synonyms
5-AS, 5-Amino-2-hydroxybenzoic acid, Mesalamine
IUPAC Name
5-Amino-2-hydroxybenzoic acid
Molecular Formula
H2NC6H3-2-(OH)CO2H
Canonical SMILES
Nc1ccc(O)c(c1)C(O)=O
InChI
1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)
InChI Key
KBOPZPXVLCULAV-UHFFFAOYSA-N
Melting Point
275-280 ℃(dec.) (lit.)
Solubility
Insoluble in ethanol
Application
5-Aminosalicylic acid is a peroxidase substrate suitable for use in ELISA procedures. This substrate produces a soluble end product that is brown in color and can be read spectrophotometrically at 450 nm. The reaction may be stopped with 3 N NaOH and read at 550 nm.
Form
powder with small lumps
Gene Information
human ALOX5(240), PPARG(5468), PTGS1(5742), PTGS2(5743)
Monoisotopic Mass
153.042593085
Reaction Suitability
reaction type: solution phase peptide synthesis
Safety Description
26-36-24/25
Supplemental Hazard Statements
H315-H319-H335
Topological Polar Surface Area
83.6 Ų