Maxwell T1, Chun SY1, Lee KS1, Kim S1, Nam KS1.
Int J Oncol. 2016 Dec 29. doi: 10.3892/ijo.2016.3825. [Epub ahead of print]Arctigenin is a plant lignan extracted from Arctium lappa that has been shown to have estrogenic properties. In spite of the health benefits of phytoestrogens reducing the risk of osteoporosis, heart disease, and menopausal symptoms, its benefits against the risk of breast cancer have not been fully elucidated. Thus, we investigated the effects of arctigenin on metastasis of breast cancer using both estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 human breast cancer cell lines to see if the effects are dependent on the status of ER expression. Read More