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Catalog Number
ACM5657170-1
Product Name
Ethylenediamine-N,N'-diacetic acid
Structure
CAS
5657-17-0
Category
Heterocyclic Organic Compound
Description
Ethylenediaminediacetic acid is an ethylenediamine derivative in which two of the four amine protons of ethylenediamine are replaced by carboxymethyl groups. It has a role as a chelator and a bacterial xenobiotic metabolite. It is an ethylenediamine derivative, a glycine derivative, a polyamino carboxylic acid and an amino dicarboxylic acid. It is a conjugate acid of an ethylenediaminediacetate(1-).
Ethylenediamine-N,N'-diacetic acid (EDDA) is a chelating agent that can be used to synthesize: Binary and ternary copper(II) complexes with potent proteasome inhibitory properties. Pd(EDDA) complexes which can coordinate with amino acids, peptides, or DNA units.
Storage
Store at 2-8 ℃
Complexity
142
Covalently-Bonded Unit Count
1
EC Number
227-105-6
Exact Mass
176.08
Hazard Codes
Xi: Irritant;
Hazard Statements
Xi: Irritant;
H-Bond Acceptor
6
H-Bond Donor
4
Heavy Atom Count
12
Hydrogen Bond Acceptor Count
6
Hydrogen Bond Donor Count
4
MDL Number
MFCD00004281
Monoisotopic Mass
176.07970687
Physical State
Solid
PSA
98.66
Refractive Index
1.509
Rotatable Bond Count
7
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Application of EDDA as a Ligand in the Synthesis of Radioactive Tracers
Najmeh Rahmanian, et al. Medicinal Chemistry Research, 2018, 27, 890-902.
Coligands such as ethylenediamine-N,N'-diacetic acid (EDDA) which also have impacts on pharmacokinetic properties of the resulting radiolabeled peptide have been used to occupy the remaining cores of 99mTc. Radiolabeling of HYNIC-SSS-GE11 conjugated peptide · Labeling of HYNIC-(Ser)3-GE11 with 99mTc Labeling of HYNIC-(Ser)3-GE11 with 99mTc using an exchange ligand approach in the presence of both tricine and EDDA at 95°C gave 99mTc-EDDA/tricine-HYNIC- (Ser)3-GE11 with RCP of 99% (n = 10). · Briefly, 50 µL solution of tricine (200 mg/mL in 0.5 M ammonium acetate buffer of pH 6.5), 200 µL solution of EDDA (25 mg/mL in 0.5 M ammonium acetate buffer of pH 6.5), 40 µL solution of SnCl2. · 2H2O (1 mg/mL in 0.1 N HCl) and 100-300 MBq solution of the freshly eluted 99mTc-pertecnetate were added to 10 µL solution of peptide (1 mg/mL in water) in a microcentrifuge tube and incubated at 95°C for 10 min.
EDDA-Based Molecular Probes for Micro-SPECT/CT Imaging
Zhang, Yiqiu, et al. Chemical Biology & Drug Design, 2019, 93(4), 447-453.
Ethylenediamine-N,N'-dacetic acid (EDDA) can be used to synthesize a new (99m)Tc-tricine-EDDA-Hynic-c-Met molecular probe, and further used to screen c-Met indicators of NSCLC in the H1993 nude mouse model, for targeted drug therapy. Preparation of (99m)Tc-tricine-EDDA-Hynic-c-Met · Tricine-EDDA solution was prepared by dissolving 20 mg/mL triglycine and 10 mg/mL EDDA in water, pH 6.0 to 7.0. · In a 1.5 mL centrifuge tube, 25 μL Hynic-c-Met solution (1mg/mL) and 100 μL tricine-EDDA solution were added, followed by adding 65 μL Na99mTcO4 eluent 1 mci and 10 μL SnCl2 solution (1 mg/mL dissolved in 0.1 mol/L HCl), which were reacted in water bath at 30°C for 30min.
Synthesis of EDDA-Based (99m)Tc-5-Fluorouracil for Brain Imaging
Ahmed, N., et al. Journal of Radioanalytical and Nuclear Chemistry, 2016, 309, 805-811.
EDDA can modify the labeling surface of (99m)Tc-5-fluorouracil, which is an anti-tumor agent for solid tumors. The obtained EDDA-(99m)Tc-5-fluorouracil can be localized in the brain and therefore can be further used for brain imaging studies. Synthesis Procedure of EDDA-based (99m)Tc-5-fluorouracil · The sample vial contained 10 mg/ml of 5-fluorouracil and 300 μg of stannous chloride in 0.5 ml of 0.9 % normal saline (marked as Vial I-A). · 2.5 mg of EDDA, 300 μg of disodium hydrogen phosphate dodecahydrate and 0.1 ml of 0.05 N Sodium hydroxide were taken in other vial with final volume of 0.5 ml marked as Vial I-B and transferred to the Vial I-A. · After 15 min, 500 ± 20 MBq/0.5 ml of sodium pertechnetate was added to the vial with a final volume of 1.5 ml; pH was adjusted at 7.0 ± 0.5 and incubated at 80 °C for 15 min. · The sample vial was then allowed to cool at temperature for 30 min. The solution was sterilized by passing through 0.2 lm syringe filter. Radiochemical purity was checked by ITLC.
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Najmeh Rahmanian, et al. Medicinal Chemistry Research, 2018, 27, 890-902.
Zhang, Yiqiu, et al. Chemical Biology & Drug Design, 2019, 93(4), 447-453.
Ahmed, N., et al. Journal of Radioanalytical and Nuclear Chemistry, 2016, 309, 805-811.
