Catalog Number
ACM111662647-1
Product Name
Fmoc-Gla(OtBu)2-OH
Description
Fmoc-Gla(OtBu)2-OH is a building block for the introduction of γ-carboxyglutamic acid (Gla). γ-Carboxylation of glutamic acid is a rare post-translational modification that occurs in blood coagulation factors and in some snake and cone snail venoms.
Synonyms
Fmoc-Gla(OtBu)2-OH, Fmoc-γ-carboxy-Glu(OtBu) 2-OH, Fmoc-gamma-carboxy-L-glutamic acid gamma,gamma-di-t-butyl ester
Molecular Formula
C29H35NO8
InChI
1S/C29H35NO8/c1-28(2,3)37-25(33)21(26(34)38-29(4,5)6)15-23(24(31)32)30-27(35)36-16-22-19-13-9-7-11-17(19)18-12-8-10-14-20(18)22/h7-14,21-23H,15-16H2,1-6H3,(H,30,35)(H,31,32)/t23-/m0/s1
InChI Key
XJRUHYXXHXECDI-QHCPKHFHSA-N
Application
Peptide synthesis.
Functional Group
carboxylic acid
Reaction Suitability
reaction type: Fmoc solid-phase peptide synthesis
Type
Unusual Amino Acids, Analogs of Aspartic and Glutamic Acids
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