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Home > Product > Material & Chemicals > Polymer/Macromolecule > 4-Sulfo-1,8-naphthalic anhydride potassium salt

4-Sulfo-1,8-naphthalic anhydride potassium salt | CAS Number: 71501-16-1

Catalog Number
ACM71501161
Product Name
4-Sulfo-1,8-naphthalic anhydride potassium salt
Structure
CAS Number
71501-16-1
Synonyms
potassium 1,3-dioxo-1h,3h-naphtho[1,8-cd]pyran-6-sulphonate;1,8-Naphthalicanhydride-4-sulfonicacid,potassiumsalt;1H,3H-Naphtho[1,8-cd]pyran-6-sulfonicacid,1,3-dioxo-,potassiumsalt;3h-naphtho[1,8-cd]pyran-6-sulfonicacid,1,3,-dioxo-1potassiumsalt;4-SULFO-1,
Molecular Weight
316.33
Molecular Formula
C12H5KO6S
Purity
98%
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1Synthesis of the Pitstop family of clathrin inhibitors.

Robertson MJ1, Deane FM1, Stahlschmidt W2, von Kleist L2, Haucke V2, Robinson PJ3, McCluskey A4.

Nat Protoc. 2014 Jul;9(7):1592-606. doi: 10.1038/nprot.2014.106. Epub 2014 Jun 12.

This protocol describes the synthesis of two classes of clathrin inhibitors, Pitstop 1 and Pitstop 2, along with two inactive analogs that can be used as negative controls (Pitstop inactive controls, Pitnot-2 and Pitnot-2-100). Pitstop-induced inhibition of clathrin TD function acutely interferes with clathrin-mediated endocytosis (CME), synaptic vesicle recycling and cellular entry of HIV, whereas clathrin-independent internalization pathways and secretory traffic proceed unperturbed; these reagents can, therefore, be used to investigate clathrin function, and they have potential pharmacological applications. Read More

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