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Catalog Number
ACM67881985-2
Product Name
2-Methacryloyloxyethyl phosphorylcholine
Structure
CAS
67881-98-5
Category
Polymer/Macromolecule
Description
Methacryloyloxyethyl phosphorylcholine (MPC), containing a phosphorylcholine group in the side chain is a most suitable monomer to mimic the phospholipid polar groups contained with cell membranes. MPC block copolymers are biocompatible in nature; it shows desirable interaction with living tissues. It is hydroscopic in nature.
2-Methacryloyloxyethyl Phosphorylcholine for the Synthesis of Protein Delivery Nanocapsules
Liang S, et al. Nano Research, 2016, 9, 1022-1031.
Protein therapeutics with stealth capabilities can be successfully engineered by coating individual protein molecules with thin layers of zwitterionic polymers to resist nonspecific protein uptake. In this strategy, phosphocholine (PC) polymer nanocapsules were synthesized to extend the circulation time of the therapeutic protein and minimize its immunogenicity. In this work, 2-methacryloyloxyethyl phosphorylcholine (MPC), as a monomer, is an important synthetic raw material for PC polymer nanocapsules. Synthesis of nanocapsules with MPC · Proteins were first pre-conjugated with polymerizable acryloyl groups using N-hydroxysuccinimide ester, and encapsulated via in situ polymerization at room temperature using MPC as the monomer, BIS as the crosslinker, and ammonium persulfate and tetramethylethylenediamine as the initiator. · In the synthesis procedure, solutions of MPC and BIS were created as 10% (m/v) stock solutions in DI-water and anhydrous DMSO, respectively. These solutions were then mixed with the proteins at a specific molar ratio. The protein concentration was adjusted to 1 mg/mL with a phosphate buffer (50 mM, pH 7.0). Polymerization was initiated by adding APS and TEMED, followed by keeping at 4 °C for 2 hours.
Related Research
Applications of 2-Methacryloyloxyethyl Phosphorylcholine and Its Polymers in Biomedical Devices
Original Article: Revolutionary advances in 2-methacryloyloxyethyl phosphorylcholine polymers as biomaterials
Kazuhiko Ishihara
Journal of Biomedical Materials Research Part A, 2019, 107(5): 933-943.