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Home > Product > Material & Chemicals > Polymer/Macromolecule > 1 3-Diaminoacetone dihydrochloride

1 3-Diaminoacetone dihydrochloride | CAS Number: 207226-24-2

Catalog Number
ACM207226242
Product Name
1 3-Diaminoacetone dihydrochloride
Structure
CAS Number
207226-24-2
Synonyms
1,3-Diaminoacetonemonohydratedihydrochloride
Molecular Weight
179.05
Molecular Formula
C3H8N2O.2ClH.H2O
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1Improved safety profile of nolatrexed dihydrochoride in the ETHECC Trial when compared to the safety of the phase II program in unresectable hepatocellular carcinoma (uHCC).

Gish RG1, Wadler S1.

J Clin Oncol. 2004 Jul 15;22(14_suppl):4260.

4260 Background: We compare the patients' safety profile in the Phase III ETHECC (E) trial to the combined patient safety profile of patients treated with nolatrexed dihydrochloride (THYMITAQ) (T) in the 3 uHCC Phase II studies. T is a folate analogue inhibitor of Thymidylate Synthase (TS) that binds directly to the folate site of TS.METHODS: The hematological (H) toxicities (anemia, neutropenia, and thrombocytopenia) and non-hematological (NH) toxicities (mucositis, nausea, vomiting, diarrhea, and rash) data are compared between 117 T patients from the E trial (following the second independent Data Safety Monitoring Board [DSMB] in May 2003) and 129 T patients from the Phase II studies in HCC (Studies 008 [Stuart et al]; 014 [Mok et al]; 015 [ASCO 2003]). Read More

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Tel:1-201-478-8534
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Address: Suite 212, Waverly Plaza, 755 Waverly Avenue, Holtsville, NY 11742, USA